Figure 6: ANGPTL levels were associated with nuclear factor-kappa B or c-Jun N-terminal kinase signaling in nonalcoholic fatty liver disease. (a) ANGPTL2 mRNA levels were elevated in nonalcoholic fatty liver disease patient livers. (b) ANGPTL3 mRNA levels were downregulated in nonalcoholic fatty liver disease patient livers. (c and e) Gene signatures for nuclear factor-kappa B and c-Jun N-terminal kinase signaling were enriched in nonalcoholic fatty liver disease patients in comparison to normal controls by gene set enrichment analysis plots. (d) Gene signatures for nuclear factor-kappa B signaling were enriched for patients in the ANGPTL2-high expression group. (f) Gene signatures for c-Jun N-terminal kinase activation were enriched in the ANGPTL3-low expression